OVERVIEW OF ACTIVITY

Currently, no distinct algorithm or therapy sequence exists for the treatment of metastatic breast cancer (mBC). Instead, numerous acceptable agents and regimens represent a plethora of therapeutic options, and treatment decisions are often individualized based on variables that include specific disease characteristics, patient age, comorbidities, prior exposure to chemotherapy or endocrine/biologic therapy and the side-effect profiles of individual agents. For this reason, current management of mBC is characterized by clinical scenarios in which multiple treatment choices may be available but the optimal strategy is highly debatable and may be dependent on a diverse array of patient and tumor considerations. To provide clinicians with strategies to better address the disparate needs of patients with mBC, this series employs a unique case-based approach, including the perspectives of leading breast cancer investigators on their strategies for managing the intricacies of treatment decision-making in the metastatic setting. Upon completion of this CME activity, medical oncologists should be able to formulate an up-to-date and more complete approach to patient care.

LEARNING OBJECTIVES

• Select appropriate, individualized treatment plans for patients with mBC, based on multiple clinical and psychosocial factors.
• Utilize case-based learning, innovative communication strategies and shared clinical insight to provide comprehensive and compassionate oncology care.
• Develop a strategy for the front-line and subsequent management of HER2-positive mBC.
• Evaluate the source of pathology reporting, and retest patients with questionable or potentially inconclusive biomarker results.
• Query patients receiving systemic therapies about the incidence of specific side effects, and implement supportive measures or dose/schedule modifications as needed.
• Recall the design of ongoing clinical trials, and counsel appropriately selected patients about participation.

ACCREDITATION STATEMENT

Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATION STATEMENT

Research To Practice designates this educational activity for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

HOW TO USE THIS CME ACTIVITY

This CME activity contains an audio component. To receive credit, the participant should review the CME information, listen to the CD and complete the Post-test and Educational Assessment and Credit Form located on our website at VisitingProfs.com.

This program is supported by an educational grant from GlaxoSmithKline.

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EDITOR
Neil Love, MD

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