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Track 1 A 55-year-old woman with a 1-cm, ER-positive, HER2-positive infiltrating lobular carcinoma who initially elected treatment with alternative medicine. After six months, her tumor grew to 8 x 6 centimeters and she developed severe pain, extensive bony metastases and liver lesions.
Track 2 A 74-year-old woman who was diagnosed in 1998 with ER-positive, node-positive breast cancer and treated with tamoxifen for five years followed by letrozole, which was discontinued because of arthralgias. Three years later, she presented with diffuse bony metastases.
Track 3 A 55-year-old woman who was treated with CMF in 1999 for ER-negative, node-positive breast cancer and experienced a local recurrence after four years, for which she underwent a second lumpectomy. Subsequently she developed a 3-cm, triple-negative contralateral breast tumor and received neoadjuvant chemotherapy but was lost to follow-up until 2007, when she presented with locally advanced breast cancer and a solitary 3- x 2-cm liver lesion, the biopsy of which was consistent with her primary tumor.
Track 4 A 54-year-old woman with ER-negative, HER2-positive, node-positive breast cancer and bilateral pulmonary nodules consistent with metastatic disease.
Track 5 A 60-year-old retired nurse with a Grade III, ER-negative, HER2-borderline (IHC 2+, FISH 2.06), node-positive inflammatory breast tumor.
Track 6 A 45-year-old woman who was treated for ER-negative, inflammatory breast cancer 10 years ago and shortly thereafter developed a postmastectomy, HER2-positive chest wall recurrence and a solitary brain metastasis, for which she has received successive anti-HER2 therapies.